Yong Qin
Professor and Dean of Medical Chemistry
West China School of Pharmacy, Sichuan University
Address: Renmin South Road 3rd Section 17#, Chengdu, Sichuan, China 610041
Tel: 028-8550-3842
E-mail: yongqin@scu.edu.cn
Education:
1985-1989 B.S., Department of Chemistry, Yunnan University
1989-1992 Ms. of Organic Chemistry, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences（ Prof. Jiqiu Yang）
1992-1995 PhD of Organic Chemistry, Institute of Chemistry, Chinese Academy of Sciences（Prof. Zhitang Huang and Yaozhong Jiang）
1995-1996 Assistant Professor, Associate Professor of Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences
1996-2000 Postdoc Associate, Department of Chemistry, the University of Vermont, working with Prof. Martin E. Kuehne
Industrial Experience:
2000-2003 Research scientist, Triad Therapeutics Inc., San Diego
Academic Experience:
2011-2014 Prof. of synthetic organic chemistry/medicinal natural product, Innovative Drug Research Centre, Chongqing university
2003-present Prof. of synthetic organic chemistry/medicinal natural product, West china school of Pharmacy, Sichuan university
Research Interests
Total synthesis of structurally and biologically interesting natural products
Research projects in progress
Key projects of National Natural Science Foundation of China：21732005
Major sub projects of Natural Science Foundation of China：21991114
Innovative research group projects of Natural Science Foundation of China：21921002
Major new drug special sub-project of the Ministry of science and technology：2018ZX09711003-015
Awards and Honors：
Excellent youth of Sichuan Province 2004
Youth Science and Technology Award of Sichuan Province 2005
Changjiang Distinguished Professor 2009
The New Century National Hundred, Thousand and Ten Thousand Talent Project 2009
The expert who enjoy the State council special allowance 2009
Excellent “Expert with Outstanding Contribution” issued by Chengdu City 2009
The National Science Foundation for Distinguished Young Scholars 2009
The 8th academic leaders of Sichuan Province 2010
National 100 Outstanding Doctoral Dissertations, as supervisor 2010
The first Weishan natural product synthesis award of Chinese Chemical Society 2013
The 18th China Patent Award of Excellence of the National Intellectual Property Administration 2016
The first prize for natural science of the ministry of education 2017
Chief Expert of Health and Family Planning Commission of Sichuan Province 2017
The third Yiling BioMed innovation award of Chinese Pharmaceutical Association 2018
The 20th Wu Jieping-Paul Janssen Medical & Pharmaceutical Award ( Wu-Janssen Award ) 2019
Representative Publication：
（1）Liu, X.-Y.; Qin, Y.* Indole Alkaloid Synthesis Facilitated by Photoredox Catalytic Radical Cascade Reactions. Acc. Chem. Res. 2019, 52, 1877-1891.
（2）Nie, W.; # Gong, J.; # Chen, Zh.-H.; Liu, J.- Zh.; Tian, D.; Song, H.; Liu, X.-Y.; Qin, Y.* Enantioselective Total Synthesis of (−)-Arcutinine. J. Am. Chem. Soc. 2019, 141, 9712.
（2）Nie, W.; # Gong, J.; # Chen, Zh.-H.; Liu, J.- Zh.; Tian, D.; Song, H.; Liu, X.-Y.; Qin, Y.* Enantioselective Total Synthesis of (−)-Arcutinine. J. Am. Chem. Soc. 2019, 141, 9712.
（3）Li, W.-F; # Chen, Zh.-T.; #, Yu, D.; Peng, X.; Wen, G.-H.; Wang, S.-Q.; Xue, F.; Liu, X.-Y.; Qin, Y.* Asymmetric Total Syntheses of the Akuammiline Alkaloids (‒)-Strictamine and (‒)-Rhazinoline. Angew. Chem. Int. Ed. 2019, 58, 6059.
（4）Liu, W.-T.; # Qin, W.-F.; # Wang, X.-B.; Xue, F.; Liu, X.-Y.; Qin, Y.* Bioinspired Synthesis of (+)-Cinchonidine Using Cascade Reactions. Angew. Chem. Int. Ed. 2018, 57, 12299.
（5）Xue, F.;# Wang, F.-L.;# Liu, J.- Zh.; Di, J.-M.; Liao, Q.; Lu, H.-F.; Zhu, M.; He, L.-P.; He, H.; Zhang, D.; Song, H.; Liu, X.-Y.; Qin, Y.* A Desulfurative Strategy for the Generation of Alkyl Radicals Enabledby Visible-Light Photoredox Catalysis. Angew. Chem. Int. Ed. 2018, 57, 6667.
（6）Liu, X.-Y.; Qin, Y.* Enabling Syntheses of Diterpenoid Alkaloids and Related Diterpenes by an Oxidative Dearomatization/Diels–Alder Cycloaddition Strategy. Nat. Prod. Rep. 2017, 34, 1044.
（7）Wang, X.-B.; # Xia, D-L.; # Qin, W.-F.; # Zhou, R.-J.; # Zhou, X-H.; # Zhou, Q-L.; # Liu, W.-T,; Dai, X.; Wang, H-J.; Wang, S-Q.;Tan, L.;Zhang, D.;Song, H.; Qin Y.* A Radical Cascade Enabling Collective Syntheses of Natural Products. Chem, 2017, 2, 803.
（8）Leng, L.-Y.; Zhou, X.-H.; Liao, Q.; Wang, F.-L.; Song, H.*; Zhang, D.; Liu, X.-Y.; Qin, Y.* Asymmetric Total Synthesis of Kopsia Indole alkaloids. Angew. Chem. Int. Ed. 2017, 56, 3703.
（9）Li, X.-H.; Zhu, M.; Wang, Z.-X.; Liu, X.-Y.;* Song, H.; Zhang, D.; Wang, F.-P.; Qin Y.* Synthesis of Atisine, Ajaconine, Denudatine, and Hetidine Diterpenoid Alkaloids by a Bioinspired Approach. Angew. Chem. Int. Ed. 2016, 55, 15667.
（10）Gong, J.;# Chen, H.;# Liu, X.-Y.;# Wang, Z.-X.; Nie, W.; Qin, Y.* Total Synthesis of Atropurpuran. Nat. Comm. 2016, 7, 12183.
（11）Jin, Sh.-J.; Gong, J.; Qin, Y.* Total Synthesis of (−)-Lundurine A and Determination of Absolute Configuration. Angew. Chem. Int. Ed. 2015, 54, 2228.
（12）Zhou, X.; Xiao, T.; Iwama, Y.; Qin, Y.* Biomimetic Total Synthesis of (+)-Gelsemine. Angew. Chem. Int. Ed. 2012, 51, 4909.
（13）Zhang, D.; Song, H.; Qin, Y.* Total Synthesis of Indoline Alkaloids: A cyclopropanation Strategy. Acc. Chem. Res. 2011, 44, 447.
（14）Wu, H. X.;# Xue, F.;# Xiao, X.; Qin, Y.* Total Synthesis of (+)-Perophoramidine. Determination of the Absolute Configuration. J. Am. Chem. Soc. 2010, 132, 14052.
（15）Zhang, M.; Huan, X.; Shen, L.-Q.; Qin, Y.* Total Synthesis of (±)-Vincorine. J. Am. Chem. Soc. 2009, 131, 6013.
（16）Shen, L.-Q.; # Zhang, M.; # Wu, Y.; Qin, Y.* Highly Efficient Assembly of Indole Alkaloid Skeleton via Cyclopropanation: Concise Total Synthesis of (±)-Minfiensine. Angew. Chem. Int. Ed. 2008, 47, 3618.
（17）Yajima, A.;*# Qin, Y.;*# Zhou, X.; Kawanishi, N.; Xiao, X.; Wang, J.; Zhang, D.; Wu, Y.; Nukada, T.; Yabuta, G.; Qi, J.-H.;*# Asano, T.; Sakagami, Y. Synthesis and Absolute Configuration of Hormone. Nature Chemical Biology. 2008, 4, 235.
（18）Yang, J.; Wu, H.-X.; Shen, L.-Q.; Qin, Y.* Total Synthesis of (±)-Communesin F. J. Am. Chem. Soc. 2007, 129, 13794.
（4）Liu, W.-T.; # Qin, W.-F.; # Wang, X.-B.; Xue, F.; Liu, X.-Y.; Qin, Y.* Bioinspired Synthesis of (+)-Cinchonidine Using Cascade Reactions. Angew. Chem. Int. Ed. 2018, 57, 12299.
（5）Xue, F.;# Wang, F.-L.;# Liu, J.- Zh.; Di, J.-M.; Liao, Q.; Lu, H.-F.; Zhu, M.; He, L.-P.; He, H.; Zhang, D.; Song, H.; Liu, X.-Y.; Qin, Y.* A Desulfurative Strategy for the Generation of Alkyl Radicals Enabledby Visible-Light Photoredox Catalysis. Angew. Chem. Int. Ed. 2018, 57, 6667.
（6）Liu, X.-Y.; Qin, Y.* Enabling Syntheses of Diterpenoid Alkaloids and Related Diterpenes by an Oxidative Dearomatization/Diels–Alder Cycloaddition Strategy. Nat. Prod. Rep. 2017, 34, 1044.
（7）Wang, X.-B.; # Xia, D-L.; # Qin, W.-F.; # Zhou, R.-J.; # Zhou, X-H.; # Zhou, Q-L.; # Liu, W.-T,; Dai, X.; Wang, H-J.; Wang, S-Q.;Tan, L.;Zhang, D.;Song, H.; Qin Y.* A Radical Cascade Enabling Collective Syntheses of Natural Products. Chem, 2017, 2, 803.
（8）Leng, L.-Y.; Zhou, X.-H.; Liao, Q.; Wang, F.-L.; Song, H.*; Zhang, D.; Liu, X.-Y.; Qin, Y.* Asymmetric Total Synthesis of Kopsia Indole alkaloids. Angew. Chem. Int. Ed. 2017, 56, 3703.
（9）Li, X.-H.; Zhu, M.; Wang, Z.-X.; Liu, X.-Y.;* Song, H.; Zhang, D.; Wang, F.-P.; Qin Y.* Synthesis of Atisine, Ajaconine, Denudatine, and Hetidine Diterpenoid Alkaloids by a Bioinspired Approach. Angew. Chem. Int. Ed. 2016, 55, 15667.
（10）Gong, J.;# Chen, H.;# Liu, X.-Y.;# Wang, Z.-X.; Nie, W.; Qin, Y.* Total Synthesis of Atropurpuran. Nat. Comm. 2016, 7, 12183.
（11）Jin, Sh.-J.; Gong, J.; Qin, Y.* Total Synthesis of (−)-Lundurine A and Determination of Absolute Configuration. Angew. Chem. Int. Ed. 2015, 54, 2228.
（12）Zhou, X.; Xiao, T.; Iwama, Y.; Qin, Y.* Biomimetic Total Synthesis of (+)-Gelsemine. Angew. Chem. Int. Ed. 2012, 51, 4909.
（13）Zhang, D.; Song, H.; Qin, Y.* Total Synthesis of Indoline Alkaloids: A cyclopropanation Strategy. Acc. Chem. Res. 2011, 44, 447.
（14）Wu, H. X.;# Xue, F.;# Xiao, X.; Qin, Y.* Total Synthesis of (+)-Perophoramidine. Determination of the Absolute Configuration. J. Am. Chem. Soc. 2010, 132, 14052.
（15）Zhang, M.; Huan, X.; Shen, L.-Q.; Qin, Y.* Total Synthesis of (±)-Vincorine. J. Am. Chem. Soc. 2009, 131, 6013.
（16）Shen, L.-Q.; # Zhang, M.; # Wu, Y.; Qin, Y.* Highly Efficient Assembly of Indole Alkaloid Skeleton via Cyclopropanation: Concise Total Synthesis of (±)-Minfiensine. Angew. Chem. Int. Ed. 2008, 47, 3618.
（17）Yajima, A.;*# Qin, Y.;*# Zhou, X.; Kawanishi, N.; Xiao, X.; Wang, J.; Zhang, D.; Wu, Y.; Nukada, T.; Yabuta, G.; Qi, J.-H.;*# Asano, T.; Sakagami, Y. Synthesis and Absolute Configuration of Hormone. Nature Chemical Biology. 2008, 4, 235.
（18）Yang, J.; Wu, H.-X.; Shen, L.-Q.; Qin, Y.* Total Synthesis of (±)-Communesin F. J. Am. Chem. Soc. 2007, 129, 13794.